HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2370372Generated: October 27, 2026
tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate → {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/2370372
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate | HCID 45117839 | — |
| Reactant | 1-(4-Bromopyridin-2-yl)cyclobutane-1-carbonitrile | HCID 57417094 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester | HCID 59293719 | — |
Reaction Steps
The title compound is prepared in analogy to the procedure described in Step 1.3, but using 1-(4-bromo-pyridin-2-yl)-cyclobutanecarbonitrile (Step 19.3) and (4-methyl-thiazol-2-yl)carbamic acid tert-butyl ester (Step 18.4). The reaction mixture is stirred for 3 h at 100° C. Title compound: ESI-MS: 371.1 [M+H]+; tR=4.86 min (System 1); TLC: Rf=0.66 (Hex/EtOAc, 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08710085B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-3dc3af8587fd4259aa8b87290422ae80 |
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| Source note | uspto-grants-2014_04 |
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