HCID 59293668, compound → HCID 59293705, compound

HRID 2370374Notes

Reaction equation

HRID 2370374 reaction equation
C(OC(=O)[NH:7][C:8]1[S:9][C:10]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]([CH3:26])([CH3:25])[CH2:21][N:22]([CH3:24])[CH3:23])[CH:15]=2)=[C:11]([CH3:13])[N:12]=1)(C)(C)C>C(Cl)Cl.CO>[CH3:24][N:22]([CH3:23])[CH2:21][C:20]([C:16]1[CH:15]=[C:14]([C:10]2[S:9][C:8]([NH2:7])=[N:12][C:11]=2[CH3:13])[CH:19]=[CH:18][N:17]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 1

HCID 59293668HCID 59293668, compound

Product 1

HCID 59293705HCID 59293705, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared in analogy to the procedure described in Step 19.1 but using {5-[2-(2-dimethylamino-1,1-dimethyl-ethyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester (Step 21.2) and stirring the reaction mixture for 2 h at rt. Title compound: ESI-MS: 291.1 [M+H]+; tR=2.48 min (System 1); TLC: Rf=0.11 (DCM/MeOH, 9:1).

Workup

  1. customThe title compound is prepared in analogy to the procedure

Sources & evidence

ORD record
ord-ae8c7d98a5fa41d38c85eff71e17e760
Source dataset
uspto-grants-2014_04
Patent number
US08710085B2

Reaction notes

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