HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → (1S)-2-(methylamino)-1-pyridin-2-ylethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | (1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine | HCID 6612782 | — |
| Reactant | (R)-2-(methylamino)-1-pyridin-2-ylethanol | HCID 10149007 | — |
| Product | (1S)-2-(methylamino)-1-pyridin-2-ylethanol | HCID 39235348 | — |
Reaction Steps
As described for the preparation of (1R)-2-(methylamino)-1-pyridin-2-ylethanol (Preparations 65-69), using (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine in place of (1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine, 2-acetylpyridine was converted to the title compound, isolated as an amber oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06852731B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-c8b3f6c9228c4dc4a40f7101196bea11 |
| Source note | uspto-grants-2005_02 |