3-Amino-4-methoxybenzoic acid → HCID 25255429, compound

HRID 2370437Notes

Reaction equation

HRID 2370437 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[F:13][C:14]([F:19])([F:18])[C:15](Cl)=[O:16].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[NH2:25]>>[CH3:32][O:31][C:27]1[CH:26]=[C:24]([NH:25][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([NH:1][C:15](=[O:16])[C:14]([F:19])([F:18])[F:13])[CH:3]=2)[CH:23]=[C:22]([O:21][CH3:20])[C:28]=1[O:29][CH3:30]

Participants

4

Reactant 3

HCID 178233-Amino-4-methoxybenzoic acidHCID 322853,4,5-TrimethoxyanilineHCID 61106Trifluoroacetyl chloride

Product 1

HCID 25255429HCID 25255429, compound

Procedure

Compound 263 is synthesized following a similar method as in Example 1 and using 3-amino-4-methoxy benzoic acid, trifluoroacetyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 50%.

Sources & evidence

ORD record
ord-cedde4a8710c48fb9f27cef32ef23948
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

Loading…