Chloroacetyl chloride → HCID 25256707, compound

HRID 2370441Notes

Reaction equation

HRID 2370441 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[Cl:13][CH2:14][C:15](Cl)=[O:16].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:29][CH3:30])[C:26]=1[O:27][CH3:28])[NH2:23]>>[CH3:30][O:29][C:25]1[CH:24]=[C:22]([NH:23][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([NH:1][C:15](=[O:16])[CH2:14][Cl:13])[CH:3]=2)[CH:21]=[C:20]([O:19][CH3:18])[C:26]=1[O:27][CH3:28]

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 178233-Amino-4-methoxybenzoic acidHCID 322853,4,5-Trimethoxyaniline

Product 1

HCID 25256707HCID 25256707, compound

Procedure

Compound 1 is synthesized following a similar method as in Example 1 and using 3-amino-4-methoxybenzoic acid, 2-chloroacetyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 56%.

Sources & evidence

ORD record
ord-3fc157d5597447f0bf4bed20fffcfd74
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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