3,4,5-Trimethoxyaniline → HCID 58360088, compound

HRID 2370442Notes

Reaction equation

HRID 2370442 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[NH2:12])[C:6]([OH:8])=O.[C:13](Cl)(=[O:16])[CH2:14][CH3:15].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:29][CH3:30])[C:26]=1[O:27][CH3:28])[NH2:23]>>[CH3:30][O:29][C:25]1[CH:24]=[C:22]([NH:23][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:11]([NH:12][C:13](=[O:16])[CH2:14][CH3:15])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:21]=[C:20]([O:19][CH3:18])[C:26]=1[O:27][CH3:28]

Participants

4

Reactant 3

HCID 322853,4,5-TrimethoxyanilineHCID 62324Propionyl chlorideHCID 2880572486-69-3

Product 1

HCID 58360088HCID 58360088, compound

Procedure

Compound 64 is synthesized following a similar method as in Example 1 and using 3-methoxy-4-aminobenzoic acid, propionyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 57%.

Sources & evidence

ORD record
ord-301c9418ca534fb1aa99d3e4d7c92149
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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