3,4,5-Trimethoxyaniline → HCID 67321040, compound

HRID 2370443Notes

Reaction equation

HRID 2370443 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:13](Cl)(=[O:16])[CH2:14][CH3:15].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:29][CH3:30])[C:26]=1[O:27][CH3:28])[NH2:23]>>[CH3:30][O:29][C:25]1[CH:24]=[C:22]([NH:23][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:2]=2[NH:1][C:13](=[O:16])[CH2:14][CH3:15])[CH:21]=[C:20]([O:19][CH3:18])[C:26]=1[O:27][CH3:28]

Participants

4

Reactant 3

HCID 322853,4,5-TrimethoxyanilineHCID 62324Propionyl chlorideHCID 3510102-Amino-4-methoxybenzoic acid

Product 1

HCID 67321040HCID 67321040, compound

Procedure

Compound 63 is synthesized following a similar method as in Example 1 and using 2-amino-4-methoxybenzoic acid, propionyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 64%.

Sources & evidence

ORD record
ord-fe2478b01d314246a10c1fb94d1f4bcb
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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