Propionyl chloride → HCID 58360082, compound

HRID 2370444Notes

Reaction equation

HRID 2370444 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=O.[C:12](Cl)(=[O:15])[CH2:13][CH3:14].[F:17][C:18]([F:28])([F:27])[O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1>>[F:17][C:18]([F:27])([F:28])[O:19][C:20]1[CH:26]=[CH:25][C:23]([NH:24][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([NH:1][C:12](=[O:15])[CH2:13][CH3:14])[CH:3]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 62324Propionyl chlorideHCID 755683-Amino-4-methylbenzoic acidHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 58360082HCID 58360082, compound

Procedure

Compound 69 is synthesized following a similar method as in Example 1 and using 3-amino-4-methylbenzoic acid, propionyl chloride and 4-trifluoromethoxyaniline as materials. Total yield of the two steps: 49%.

Sources & evidence

ORD record
ord-e41cddf2e1a6470cb38ab55017343d75
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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