3,4,5-Trimethoxyaniline → HCID 67320508, compound

HRID 2370445Notes

Reaction equation

HRID 2370445 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[F:11])[C:5]([OH:7])=O.[C:14](Cl)(=[O:17])[CH2:15][CH3:16].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[NH2:24]>>[CH3:31][O:30][C:26]1[CH:25]=[C:23]([NH:24][C:5](=[O:7])[C:4]2[CH:8]=[C:9]([O:12][CH3:13])[C:10]([F:11])=[C:2]([NH:1][C:14](=[O:17])[CH2:15][CH3:16])[CH:3]=2)[CH:22]=[C:21]([O:20][CH3:19])[C:27]=1[O:28][CH3:29]

Participants

4

Reactant 3

HCID 322853,4,5-TrimethoxyanilineHCID 62324Propionyl chlorideHCID 67320966HCID 67320966, compound

Product 1

HCID 67320508HCID 67320508, compound

Procedure

Compound 75 is synthesized following a similar method as in Example 1 and using 3-amino-4-fluoro-5-methoxybenzoic acid, propionyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 76%.

Sources & evidence

ORD record
ord-027c3335a28548139bfe11a30920db99
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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