3,4,5-Trimethoxyaniline → HCID 67320406, compound

HRID 2370446Notes

Reaction equation

HRID 2370446 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([F:13])=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[C:14](Cl)(=[O:17])[CH2:15][CH3:16].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[NH2:24]>>[CH3:31][O:30][C:26]1[CH:25]=[C:23]([NH:24][C:5](=[O:7])[C:4]2[C:8]([F:13])=[CH:9][C:10]([O:11][CH3:12])=[C:2]([NH:1][C:14](=[O:17])[CH2:15][CH3:16])[CH:3]=2)[CH:22]=[C:21]([O:20][CH3:19])[C:27]=1[O:28][CH3:29]

Participants

4

Reactant 3

HCID 322853,4,5-TrimethoxyanilineHCID 62324Propionyl chlorideHCID 67319831HCID 67319831, compound

Product 1

HCID 67320406HCID 67320406, compound

Procedure

Compound 79 is synthesized following a similar method as in Example 1 and using 3-amino-4-methoxy-6-fluorobenzoic acid, propionyl chloride and 3,4,5-trimethoxyaniline as materials. Total yield of the two steps: 66%.

Sources & evidence

ORD record
ord-191fc397c2c44ad3959fffc4f20722af
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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