N-(5-Amino-2-methoxyphenyl)propanamide → HCID 67321259, compound

HRID 2370448Notes

Reaction equation

HRID 2370448 reaction equation
[C:1]([NH:5][C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[NH2:9])(=[O:4])[CH2:2][CH3:3].[CH3:15][O:16][C:17]1[CH:18]=[C:19]([S:27](O)(=[O:29])=[O:28])[CH:20]=[C:21]([O:25][CH3:26])[C:22]=1[O:23][CH3:24]>>[C:1]([NH:5][C:6]1[CH:7]=[C:8]([NH:9][S:27]([C:19]2[CH:18]=[C:17]([O:16][CH3:15])[C:22]([O:23][CH3:24])=[C:21]([O:25][CH3:26])[CH:20]=2)(=[O:29])=[O:28])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14])(=[O:4])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 16481153N-(5-Amino-2-methoxyphenyl)propanamideHCID 18667734HCID 18667734, compound

Product 1

HCID 67321259HCID 67321259, compound

Procedure

Compound 91 is synthesized following a similar method as in Example 1 and using 3-propionamido-4-methoxyaniline and 3,4,5-trimethoxybenzenesulfonic acid as materials. Total yield of the two steps: 40%.

Sources & evidence

ORD record
ord-f1aebfc4294942d9985e2d5640633499
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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