3-Amino-4-methoxybenzoic acid → HCID 56944057, compound

HRID 2370449Notes

Reaction equation

HRID 2370449 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].[F:13][C:14]([F:19])([F:18])[C:15](Cl)=[O:16].[CH3:20][O:21][C:22]1[CH:23]=[C:24](O)[CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29]>>[F:13][C:14]([F:19])([F:18])[C:15]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([O:7][C:24]1[CH:25]=[C:26]([O:30][CH3:31])[C:27]([O:28][CH3:29])=[C:22]([O:21][CH3:20])[CH:23]=1)=[O:6])=[O:16]

Participants

4

Reactant 3

HCID 178233-Amino-4-methoxybenzoic acidHCID 61106Trifluoroacetyl chlorideHCID 695053,4,5-Trimethoxyphenol

Product 1

HCID 56944057HCID 56944057, compound

Procedure

Compound 353 is synthesized following a similar method as in Example 1 and using 3-amino-4-methoxybenzoic acid, trifluoroacetyl chloride and 3,4,5-trimethoxyphenol as materials. Total yield of the two steps: 46%.

Sources & evidence

ORD record
ord-123f00e1ab95433e916d0bdfea512eca
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

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