4-Chloroaniline → HCID 56945105, compound

HRID 2370451Notes

Reaction equation

HRID 2370451 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[C:13](Cl)(=[O:16])[CH2:14][CH3:15].[Cl:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:25]=[CH:24][C:22]([NH:23][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([NH:1][C:13](=[O:16])[CH2:14][CH3:15])[CH:3]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 78124-ChloroanilineHCID 178233-Amino-4-methoxybenzoic acidHCID 62324Propionyl chloride

Product 1

HCID 56945105HCID 56945105, compound

Procedure

Compound 2613 is synthesized following a similar method as in Example 1 and using 3-amino-4-methoxybenzoic acid, propionyl chloride and 4-chloroaniline as materials. Total yield of the two steps: 56%.

Sources & evidence

ORD record
ord-b06cec8ead4a4f0e8e1c452bd1673d23
Source dataset
uspto-grants-2014_04
Patent number
US08710098B2

Reaction notes

Loading…