Triethylamine → HCID 5243946, compound

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Reaction Steps

0.6 g 3-amino-4-methoxybenzoic acid (1.0 g, 6 mmol) is dissolved in dry tetrahydrofuran in a 25 ml flask, triethylamine (1.2 ml, 12 mmol) is added into the solution to obtain a transparent yellow solution. The flask in placed in an ice-water bath, the mixture is stirred under nitrogen protection, propionyl chloride (0.78 ml, 9 mmol) is added drop wise into the mixture. After drop wise addition, the mixture stands at room temperature and is allowed to react. The resulted reactant is subsequently filtered, the filtrate is evaporated to dryness and the residue is separated in a silica column to obtain 1.3 g 3-propionamido-4-methoxybenzoic acid.

Provenance & Evidence