HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,2R)-(-)-1-Amino-2-indanol → 4-[2-((1S,2R)-2-Hydroxy-indan-1-ylamino)-benzooxazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| Reactant | N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide | HCID 57725414 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 4-[2-((1S,2R)-2-Hydroxy-indan-1-ylamino)-benzooxazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 24821930 | — |
Reaction Steps
A solution of 4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)-N-methylpyridine-2-carboxamide (17 mg, 0.05 mmol, 1.0 eq) and (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol (30 mg, 0.2 mml, 4.0 eq) in 1 mL of N,N-dimethylacetamide was heated in the microwave at 90° C. for 600 seconds. The crude product was purified by reverse phase prep HPLC to give the title compound. MH==417.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710048B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-b80a5ab5a4fa4b2babbab76f0975bf08 |
| Source note | uspto-grants-2014_04 |