Ethyl 1-cyanocyclohexane-1-carboxylate → Ethyl 1-(aminomethyl)cyclohexane-1-carboxylate

HRID 2370494ノート

反応式

HRID 2370494 の反応式
[CH2:1]([O:3][C:4]([C:6]1([C:12]#[N:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H]>[Ni].C(O)C>[CH2:1]([O:3][C:4]([C:6]1([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 10997650Ethyl 1-cyanocyclohexane-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 21840381Ethyl 1-(aminomethyl)cyclohexane-1-carboxylate収率 80%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒2 回

実験手順

Excess Raney Nickel in an ethanol slurry was added to a solution of 1-cyano-cyclohexanecarboxylic acid ethyl ester in ethanol under a nitrogen atmosphere. The nitrogen atmosphere was replaced with excess hydrogen gas and the mixture was allowed to stir overnight. The reaction mixture was filtered through celite and the solvent was removed. The compound was clean enough to continue without purification. 80% yield. MH+=186.2.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent was removed
  3. customto continue without purification

出典と根拠

ORDレコード
ord-56f6cdc0c4834d1daa71102452638afb
出典データセット
uspto-grants-2014_04
特許番号
US08710048B2

反応ノート

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