4-Chloro-7-(trifluoromethyl)quinoline → HCID 21314806, compound

HRID 237050Notes

Reaction equation

HRID 237050 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][N:29]([S:32]([C:35]3[CH:40]=[CH:39][C:38]([CH2:41][CH2:42][CH3:43])=[C:37]([F:44])[CH:36]=3)(=[O:34])=[O:33])[CH2:28][CH2:27]2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[F:44][C:37]1[CH:36]=[C:35]([S:32]([N:29]2[CH2:30][CH2:31][N:26]([S:23]([C:20]3[CH:19]=[CH:18][C:17]([NH:16][C:2]4[C:11]5[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=5)[N:5]=[CH:4][CH:3]=4)=[CH:22][CH:21]=3)(=[O:25])=[O:24])[CH2:27][CH2:28]2)(=[O:33])=[O:34])[CH:40]=[CH:39][C:38]=1[CH2:41][CH2:42][CH3:43]

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21314871HCID 21314871, compound

Product 1

HCID 21314806HCID 21314806, compound

Procedure

In the manner given in Example 1C, 4-chloro-7-(trifluoromethyl)quinoline is heated with 1-[(p-aminophenyl)sulfonyl]-4-[(3-fluoro-4-propylphenyl)-sulfonyl]piperazine to give 1-[(3-fluoro-4-propylphenyl)sulfonyl]-4-[[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]phenyl]sulfonyl]piperazine.

Sources & evidence

ORD record
ord-27b030263b4a4fdd8baf63c9be93aa44
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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