HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide → 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide | HCID 57725414 | — |
| Reactant | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamine | HCID 57725501 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide | HCID 57725579 | — |
Reaction Steps
To a solution of 1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-ethylamine (3 eq) in THF was added 4-(2-methanesulfinyl-benzooxazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (1 eq). This was stirred at room temperature for 8 hours, concentrated and the residue was purified by preparatory reverse phase HPLC. MH+=447.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710048B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-e97f334a6cfa450b8285ab30fdd4d2f4 |
| Source note | uspto-grants-2014_04 |