Water → HCID 46947723, compound

Participants

Reaction Conditions

Reaction Steps

Oxone® (566 mg, 0.93 mmole) is added to a solution of the compound of Example 2 (200 mg, 0.31 mmole) in THF (6 ml). The reaction mixture is completed with water (3 ml) and stirred at 23° C. for 3 h 30, the time necessary for the total conversion of the starting product. The mixture is then poured into water (25 ml) and extracted with AcOEt (2×25 ml). After decantation, the organic phases are combined and washed with salt water (20 ml), dried over Na2SO4, filtered and concentrated to dryness under vacuum. The evaporation residue is purified on a silica column (eluent: Heptane/AcOEt: 1/1 to 3/7). The expected compound is obtained in the form of a colourless oil with a yield of 89% (185 mg).

Provenance & Evidence