HCID 46947722, compound → HCID 87134732, compound

HRID 2370609Notes

Reaction equation

[CH3:1][C:2]1([CH3:46])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:20])[CH2:16][N:17]([CH3:19])[CH3:18])=[C:10]([C:21]([F:24])([F:23])[F:22])[CH:9]=2)[C:4](=[O:25])[N:3]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][S:35][CH2:36][CH2:37][CH2:38][C:39]([F:45])([F:44])[C:40]([F:43])([F:42])[F:41].CC1(C)N(CCCCCCCCCSCCCC(F)(F)C(F)(F)F)C(=[O:73])N(C2C=CC([N+]([O-])=O)=C(C(F)(F)F)C=2)C1=O>>[CH3:1][C:2]1([CH3:46])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:20])[CH2:16][N:17]([CH3:18])[CH3:19])=[C:10]([C:21]([F:24])([F:23])[F:22])[CH:9]=2)[C:4](=[O:25])[N:3]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][S:35]([CH2:36][CH2:37][CH2:38][C:39]([F:45])([F:44])[C:40]([F:41])([F:42])[F:43])=[O:73]

Participants

Reactant 2

HCID 46947722HCID 46947722, compound

HCID 87134921HCID 87134921, compound

Product 1

HCID 87134732HCID 87134732, compoundYield 65%

Procedure

Compound 43a described below was synthesized according to a method similar to that described in Example 2 using the compound of Example 42 as starting reagent replacing the compound of Example 1. The expected compound is obtained in the form of a pale yellow oil with a yield of 65%.

Workup

custombelow was synthesized

Sources & evidence

ORD record: ord-a58d8bdcba55496c81cfd28291ed00f1
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08710091B2

Reaction notes

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