Trifluoroacetamide → HCID 178429266, compound

Participants

Reaction Conditions

Reaction Steps

2,2,2-trifluoroacetamide (106 mg, 0.94 mmole), magnesium oxide (76 mg, 4 eq.), rhodium acetate in the dimer form (5.2 mg, 0.025 eq.) and iodobenzene diacetate (228 mg, 1.5 eq.) are added at 23° C. to a solution of Example 1 (300 mg, 0.48 mmole) in anhydrous CH2Cl2 (5 ml). Stirring is maintained for 6 hours at 23° C. then the reaction mixture is filtered under vacuum. The filtrate is poured into water (25 ml) and extracted with AcOEt (2×25 ml). The organic phases are combined and washed successively with water (25 ml) and salt water (25 ml). After drying over Na2SO4, the organic solution is filtered and concentrated under vacuum. The evaporation residue is purified on a silica column (eluent: Heptane/AcOEt:5/5 to 3/7). After collection and concentration of the pure fractions, the expected compound is obtained in the form of a colourless oil with a yield of 34% (77 mg).

Provenance & Evidence