4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 136398794, compound

HRID 237062Notes

Reaction equation

HRID 237062 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2[C:8](=[O:16])[NH:9][C:10](SC)=[N:11][C:12]=2[CH3:13])=[CH:4][CH:3]=1.[CH3:19][C:20]1[NH:24][CH:23]=[N:22][C:21]=1[CH2:25][S:26][CH2:27][CH2:28][NH2:29]>>[ClH:1].[ClH:1].[CH3:19][C:20]1[NH:24][CH:23]=[N:22][C:21]=1[CH2:25][S:26][CH2:27][CH2:28][NH:29][C:10]1[NH:9][C:8](=[O:16])[C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:18][CH:17]=2)=[C:12]([CH3:13])[N:11]=1

Participants

3

Reactant 2

HCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 135617937HCID 135617937, compound

Product 1

HCID 136398794HCID 136398794, compound

Procedure

Reaction of 5-(4-chlorobenzyl)-6-methyl-2-methylthio-4-pyrimidone (1.95 g) with 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.19 g) by the method described in Example 1(ii) gave the title compound, m.p. 203°-206.5°. (Crystallised from ethanol).

Sources & evidence

ORD record
ord-4d640b2d07554cef9a438fb958a06417
Source dataset
uspto-grants-1979_06
Patent number
US04159329

Reaction notes

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