tert-Butyl (4-aminophenyl)carbamate → {4-[4-(2-Chloro-phenyl)-5-oxo-4,5-dihydro-3,4,7,9,9b-pentaaza-cyclopenta[a]naphthalen-8-ylamino]-phenyl}-carbamic acid tert-butyl ester

Participants

Reaction Steps

A mixture of Example 1E (330.0 mg, 0.917 mmol) and tert-butyl 4-aminophenylcarbamate (306 mg, 1.468 mmol) was heated in a capped vial at 100° C. for 1 hour. The residue was dissolved in ethyl acetate and washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4, filtered, concentrated, and purified on a 40 g column using the ISCO Companion flash system eluting with hexane/ethyl acetate (5:5 to 4:6) to provide the title compound.

Provenance & Evidence