Phosphorus oxychloride → HCID 68194586, compound

Participants

Reaction Steps

A mixture of Example 95A (0.960 g, 2.83 mmol) in POCl3 (3.5 ml, 37.5 mmol) and diisopropylethylamine (DIEA) (3.5 ml, 20.04 mmol) was heated at 90° C. for 1.5 hours. After concentrating the reaction mixture, the residue was treated with ice and aqueous NaHCO3 solution and extracted with ethyl acetate. The organic layer was dried over MgSO4, filtered, concentrated and purified on a 40 g silica column using the ISCO Companion flash system eluting with hexane/ethyl acetate (7:3 to 6:4) to provide the title compound.

Provenance & Evidence