Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 3767968, compound

HRID 2370634Notes

Reaction equation

[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1C.N1CCCNCC1>>[CH3:10][C:11]1[CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=[CH:15][C:1]=1[N:2]1[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

Reactant 3

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-

HCID 68163Hexahydro-1,4-diazepine

HCID 2283491-Methylhomopiperazine

Product 1

HCID 3767968HCID 3767968, compound

Procedure

The title compound was prepared as described in Example 100A, substituting (2-fluoro-5-nitrophenyl)methanol and 1-methyl-1,4-diazepane with 1-fluoro-2-methyl-4-nitrobenzene and 1,4-diazepane (0.7 more equivalent), respectively.

Sources & evidence

ORD record: ord-ae92f80cefcc4857ac7df0b667fa825e
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08710065B2

Reaction notes

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