Tributylvinyltin → HCID 56945760, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-bromo-4-nitrophenyl)-4-methylpiperazine (0.900 g, 3.00 mmol), tetrakis(triphenylphosphine)palladium(0) (0.104 g, 0.090 mmol), and tributyl(vinyl)tin (0.964 mL, 3.30 mmol) in 1,4-dioxane (30 mL) was degassed and heated at 105° C. overnight. After cooling, the suspension was filtered, concentrated, and purified on a 40 g column using the ISCO Companion flash system eluting with methanol/ethyl acetate (5:95 to 10:90) to provide the title compound.

Provenance & Evidence