Nitric Acid → HCID 68194434, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 226A (2.0 g, 10.57 mmol) in trifluoroacetic acid (80 ml, 1038 mmol) was added nitric acid (0.726 ml, 10.57 mmol) dropwise at 0° C. The mixture was stirred at 0-15° C. for 5 hours. The solution was poured into ice/water (20 mL) and the pH was adjusted to 10 with NH3/H2O. The mixture was extracted with methylene chloride (4×50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated to provide the title compound.

Provenance & Evidence