HCID 68194434, compound → HCID 105456868, compound

Participants

Reaction Steps

To a solution of Example 226B (2.0 g, 8.54 mmol) in methanol (50 ml) was added Pd/C (10%, 2 g). The mixture was bubbled with hydrogen and stirred overnight. The reaction mixture was filtered through a pad of diatomaceous earth and concentrated. The crude product was purified by HPLC (C18 column, mobile phase A: 10 mM NH4HCO3 in water, mobile phase B: acetonitrile, 50-75% B) to provide the title compound. MS m/z: 205 (M+H)+. 1H NMR (400 MHz, CDCl3): δ 6.95 (d, J=8.0 Hz, 1H), 6.54 (s, 1H), 6.46 (dd, J=7.6, 2.0 Hz, 1H), 3.61-3.54 (m, 1H), 2.97-2.91 (m, 2H), 2.83-2.73 (m, 2H), 2.64 (q, J=7.2 Hz, 4H), 1.05 (t, J=6.8 Hz, 6H).

Provenance & Evidence