Sulfuric Acid → HCID 86680789, compound

HRID 2370683Notes

Reaction equation

HRID 2370683 reaction equation
[OH:1][NH:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([N:11]([CH2:13][C:14]2[S:22][C:21]3[C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:19][C:18]([C:29]4[CH:30]=[N:31][C:32]([O:35][CH3:36])=[CH:33][CH:34]=4)=[N:17][C:16]=3[CH:15]=2)[CH3:12])=[N:9][CH:10]=1)=[O:4].[S:37](=[O:41])(=[O:40])([OH:39])[OH:38]>C(Cl)Cl.CO>[S:37]([OH:41])([OH:40])(=[O:39])=[O:38].[OH:1][NH:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:11]([CH2:13][C:14]2[S:22][C:21]3[C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:19][C:18]([C:29]4[CH:30]=[N:31][C:32]([O:35][CH3:36])=[CH:33][CH:34]=4)=[N:17][C:16]=3[CH:15]=2)[CH3:12])=[N:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 54575456N-Hydroxy-2-[{[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino]pyrimidine-5-carboxamide

Product 1

HCID 86680789HCID 86680789, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

To a suspension of Compound 1 (200 mg, 0.39 mmol) in DCM/MeOH (30 mL/7.5 mL) was added sulfuric acid (77 mg, 0.79 mmol, in 1 mL MeOH) to form a clear solution. The reaction mixture was stirred at room temperature overnight. The precipitation occurred and tert-butyl methyl ether (60 mL) was then added. The resulting mixture was continued to stir for 1 h at room temperature. The solid was collected by filtration to afford Compound 6 as a white solid (180 mg, 76%). M.p.: 243-246° C. LCMS: 509.3 [M+1]+. 1H NMR (400 MHz, DMSO-d6): δ 3.26 (s, 3H), 3.78 (t, J=4.8 Hz, 4H), 3.96 (s, 3H), 4.03 (t, J=4.4 Hz, 4H), 5.24 (s, 3H), 6.98 (d, J=8.4 Hz, 1H), 7.50 (s, 1H), 8.54 (dd, J=8.8 Hz, 2.4 Hz, 1H), 8.76 (s, 2H), 9.12 (d, J=2.0 Hz, 1H), 11.06 (br, 1H).

Workup

  1. customto form a clear solution
  2. customThe precipitation
  3. additiontert-butyl methyl ether (60 mL) was then added
  4. stirringto stir for 1 h at room temperature
  5. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-f0ec0dc71cac4e9b875e72afe8dc04be
Source dataset
uspto-grants-2014_04
Patent number
US08710219B2

Reaction notes

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