反应详情

A solution of 1.5 g 6-fluoro-isoquinoline (5) in 4.5 ml sulfuryl chloride was heated to 60° C. in a microwave reactor (CEM Discovery) for 8 h. After cooling to room temperature the mixture was poured on ice and extracted three times with CHCl3. After drying over Na2SO4 the solvent was distilled off and the crude product was purified by flash chromatography to yield 930 mg of 9. Rt=1.37 min (Method #1). Detected mass: 182.0 (M+H+).

1. additionwas poured on ice
2. extractionextracted three times with CHCl3
3. dry with materialAfter drying over Na2SO4 the solvent
4. distillationwas distilled off
5. customthe crude product was purified by flash chromatography