反应详情

Starting from 4-chloro-6-fluoro-isoquinoline (9) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester the title compound was prepared as hydrochloride by the method described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10) followed by deprotection using 4M hydrochloric acid in isopropanol. Rt=0.79 min (Method #1). Detected mass: 277.1/279.1 (M+H+).