HCID 57647079, compound → HCID 178511694, compound

HRID 2370729Notes

Reaction equation

HRID 2370729 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](F)[CH:10]=2)[CH:5]=[N:4][CH:3]=1.C(OC(=O)[NH:19][C@H:20]1[CH2:25][CH2:24][C@@H:23]([OH:26])[CH2:22][CH2:21]1)(C)(C)C>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:26][C@@H:23]3[CH2:24][CH2:25][C@H:20]([NH2:19])[CH2:21][CH2:22]3)[CH:10]=2)[CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 57647079HCID 57647079, compoundHCID 178418813HCID 178418813, compound

Product 1

HCID 178511694HCID 178511694, compound

Procedure

Starting from 4-chloro-6-fluoro-isoquinoline (9) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester the title compound was prepared as hydrochloride by the method described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10) followed by deprotection using 4M hydrochloric acid in isopropanol. Rt=0.79 min (Method #1). Detected mass: 277.1/279.1 (M+H+).

Sources & evidence

ORD record
ord-b6c7df0915734056affddec6267f04ac
Source dataset
uspto-grants-2014_04
Patent number
US08710228B2

Reaction notes

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