6-Fluoro-7-methoxyisoquinoline → HCID 178486717, compound

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Reaction Steps

Starting from 7-methoxy-6-fluoro-isoquinoline (7) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester the title compound was prepared as trifluoroacetate by the method described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10) followed by deprotection using 4M hydrochloric acid in isopropanol and purification via preparative HPLC. Rt=0.62 min (Method #2). Detected mass: 273.19 (M+H+).

Provenance & Evidence