HCID 57646988, compound → HCID 178511710, compound

Participants

Reaction Steps

Starting from 5,6,7-trifluoro-isoquinoline (101) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester, the Boc-protected intermediate was prepared by the method described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10). Deprotection using standard procedures (see 11 or 13) gave the title compound, which was isolated as trifluoro acetate after prep. HPLC. Subsequent treatment of the obtained trifluoro acetate with 2N HCl, followed by lyophilisation gave the corresponding HCl-salt. Rt=0.86 min (Method #1). Detected mass: 279.1 (M+H+).

Provenance & Evidence