Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium peroxide | HCID 14803 | — |
| Reactant | 6-Methoxyisoquinoline | HCID 11040978 | — |
| Reactant | HCID 86640525 | HCID 86640525 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59268510 | HCID 59268510 | — |
Reaction Steps
6 g of 6-Methoxy-isoquinoline (152) were dissolved in dry THF. Under argon a 1M solution of potassium triethylborane (37.7 mL) was added dropwise. The solution was stirred for five hours, then iodoethane (3.3 mL) was added dropwise. The solution was stirred overnight, cooled to 0° C. and 96 mL of 1N NaOH and 36 mL of 35% sodium peroxide were added. After gas evolution stopped, water and dichloromethane were added, the aqueous layer was extracted three times with dichloromethane the organic layer was dried over sodium sulfate and the solvent was removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08710228B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-06f4890e2a29409cba7597b0dae2eddc |
|---|
| Source note | uspto-grants-2014_04 |
|---|
