Sodium Hydroxide → HCID 136167338, compound

Participants

Reaction Steps

1.69 g of 4-Ethyl-6-methoxy-isoquinoline (153) were dissolved in dichloroethane and stirred with 1.7 mL of boron tribromide at room temperature for 3 hours and one additional hour at 40° C. The solution was poured on ice water, pH was adjusted to 9 by addition of sodium hydroxide and the solution was extracted with dichloromethane:isopropanol 3:1. The organic layer was evaporated to dryness and the product was purified by silica gel chromatography to yield 980 mg of 154. Detected Mess: 173.9 (M+H+) (ESI)

Provenance & Evidence