Acetic Acid → 1,2,4-Triazolo(4,3-b)(1,2,4)triazine, 7-(4-chlorophenyl)-3-methyl-

Participants

Reaction Steps

A solution of 7.8 g. of p-chlorophenylglyoxal, 6.3 g. of 3,4-diamino-5-methyl-4H-1,2,4-triazole hydrochloride and 1.7 g. of sodium hydroxide in 90 ml. of 67% acetic acid is heated on a steam bath for 1/2 hour. Water is added and heating is continued until yellow crystals separate. These crystals are collected by filtration and washed with hot ethanol, giving the desired product as a yellow solid, m.p. 240° C. (dec.).

Provenance & Evidence