Hydrochloric Acid → HCID 69252172, compound

Participants

Reaction Conditions

Reaction Steps

Cyclopentyl methyl 2-(6-aminopyridin-3-ylmethyl)-2-(1-cyclopentyl-1H-imidazol-4-yl)malonate (0.30 g; 0.57 mmol) was dissolved in absolute ethanol (5 ml). At 0° C., ethanolic HCl was added. The reaction solution was left to stand at 10° C. for 48 h. It was then concentrated under reduced pressure and the residue was taken up in 2N HCl. It was heated in a microwave (3×4 min; 180° C.). This was followed by washing with EA, and the aqueous phase was neutralized with 1N NaOH and then freeze-dried. The residue was taken up in methanol and filtered twice through a cartridge (C18). Concentration of the filtrate under reduced pressure resulted in 0.10 g of 3-(6-aminopyridin-3-yl)-2-(1-cyclopentyl-1H-imidazol-4-yl)-propionic acid.

Provenance & Evidence