Trifluoroacetic acid → HCID 178499928, compound

Participants

Reaction Steps

0.20 g (1.70 mmol, 272 μl) of triethylsilane and 1.76 g (15.46 mmol, 1.19 ml) of trifluoroacetic acid were added to a solution of 1.00 g (1.55 mmol) of the compound from example 12c in 15 ml of CH2Cl2 while cooling in ice and stirring, and stirring was continued at 0° C. After 5 h, while cooling in ice, 10 ml of water were added and the pH was adjusted to 9 with 2N NaOH. The resulting precipitate was filtered off with suction, triturated in about 20 ml of CH2Cl2, filtered off with suction and dried. 0.55 g of the desired compound was obtained.

Provenance & Evidence