p-Fluoronitrobenzene → HCID 69332311, compound

Participants

Reaction Steps

A solution of 404 mg (1.00 mmol) of the compound from example 12d in 10 ml of DMF was cooled to 0° C. and, while stirring, 80 mg (2.00 mmol, 60%) of sodium hydride were added in portions. The mixture was stirred at 0° C. for 1 h and then 423 mg (3 mmol) of 4-fluoronitrobenzene were added and stirred at RT until conversion was complete. Saturated aqueous NaHCO3 solution was added to the mixture, which was extracted with EA. The organic phase was dried over Na2SO4, filtered and concentrated. The residue was purified by chromatography on silica gel. 394 mg of the title compound were obtained.

Provenance & Evidence