Acetyl chloride → HCID 66684148, compound

HRID 2370971Notes

Reaction equation

HRID 2370971 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([F:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][C:5]=2[NH2:14])[CH2:3][CH2:2]1.[C:15](Cl)(=[O:17])[CH3:16]>>[CH:1]1([C:4]2[CH:9]=[C:8]([F:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][C:5]=2[NH:14][C:15](=[O:17])[CH3:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 58065782HCID 58065782, compound

Product 1

HCID 66684148HCID 66684148, compoundYield 84%

Procedure

The general procedure described in Example 51 was followed. N-(2-cyclopropyl-4-fluoro-5-nitrophenyl)acetamide (2.04 g, 84%) was obtained from 2-cyclopropyl-4-fluoro-5-nitrobenzenamine (described in WO2011068898) and acetyl chloride.

Sources & evidence

ORD record
ord-d9692a573b454efbbd7149b5e2791256
Source dataset
uspto-grants-2014_04
Patent number
US08710223B2

Reaction notes

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