Pyridine → HCID 59174604, compound

HRID 2370980Notes

Reaction equation

HRID 2370980 reaction equation
C([O:5][C:6]([N:8]1[C:13]2[CH:14]=[C:15]([NH:18][C:19]3[N:24]=[C:23]([NH:25][C:26]4[CH:27]=[C:28]([NH:32][C:33](=[O:36])[CH:34]=[CH2:35])[CH:29]=[CH:30][CH:31]=4)[C:22]([F:37])=[CH:21][N:20]=3)[CH:16]=[CH:17][C:12]=2[O:11][CH2:10][CH2:9]1)=O)(C)(C)C.[C:38](OC(=O)C)(=O)C.N1C=CC=CC=1>C(Cl)Cl>[C:6]([N:8]1[C:13]2[CH:14]=[C:15]([NH:18][C:19]3[N:24]=[C:23]([NH:25][C:26]4[CH:27]=[C:28]([NH:32][C:33](=[O:36])[CH:34]=[CH2:35])[CH:29]=[CH:30][CH:31]=4)[C:22]([F:37])=[CH:21][N:20]=3)[CH:16]=[CH:17][C:12]=2[O:11][CH2:10][CH2:9]1)(=[O:5])[CH3:38]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 59174424HCID 59174424, compound

Product 1

HCID 59174604HCID 59174604, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by treating the product of Example 85 with acetic anhydride and pyridine in CH2Cl2 at rt for 1 hr, followed by washing with 1N HCl, then with aqueous NaHCO3, drying over Na2SO4 and removal of solvents in vacuo. MS m/z: 449.1 (M+H+).

Workup

  1. washby washing with 1N HCl
  2. dry with materialwith aqueous NaHCO3, drying over Na2SO4 and removal of solvents in vacuo

Sources & evidence

ORD record
ord-0bc5e90eed7f49e2a3164605dd15f114
Source dataset
uspto-grants-2014_04
Patent number
US08710222B2

Reaction notes

Loading…