Potassium Carbonate → HCID 15322476, compound

Participants

Reaction Steps

3-(4-methoxyphenyl)-1-(phenylsulfonyl)-1H-indole (200 mg, 0.55 mmol) and 15 eq potassium carbonate were dissolved in 40 ml MeOH under nitrogen. The mixture was heated at reflux for 16 h, cooled to rt and then concentrated to dryness. DCM and brine were added and the mixture was acidified (pH 2-4) with 2 M HCl. The aqueous layer was extracted with DCM and the combined organic layers were concentrated. The crude product was purified on silica (EtOAc/n-Heptane, 1:1). 121.1 mg 3-(4-methoxyphenyl)-1H-indole was obtained as a white solid.

Provenance & Evidence