Dimethyl Sulfoxide → HCID 67109260, compound

Participants

Reaction Conditions

Reaction Steps

4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole (37 mg, 0.12 mmol) and 2,2-bis-(4-cyanatophenyl)propane (0.6 eq) were mixed in a vial. 1.8 ml DMSO and Et3N (3 eq) were added and the mixture was heated at 120° C. in microwave. 2,2-bis-(4-cyanatophenyl)propane (5.7 eq) and Et3N (40 eq) were added and the mixture was heated at 150° C. for 25 min in microwave. Brine was added and the aqueous layer was extracted with EtOAc 6×. The combined organic layers were dried over Na2SO4 and concentrated. The crude product was taken up in DCM, filtered through cotton wool and purified on silica (EtOAc/n-Heptane 1:9-2:8). 25.7 mg 2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-1H-indole-1-carbonitrile was obtained as a yellowish solid.

Provenance & Evidence