Ethylene Oxide → HCID 63967771, compound

To a solution of 2-ethylthiophene (2 g, 17.85 mmol, 1 eq) in anhydrous diethyl ether at 0° C. was added n-BuLi (8.6 mL, 21.4 mmol, 2.5 M in hexanes, 1.2 eq) over 15 minutes. The mixture was stirred at room temperature for 30 minutes. After cooling to 0° C., a solution of ethylene oxide (1.1 mL, 21.4 mmol, 1.2 eq) in anhydrous ether was added. After stirring at 0° C. for 3 hr, the reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over Na2SO4 and concentrated to give a crude product. The crude product was purified by column chromatography.

1. temperatureAfter cooling to 0° C.
2. stirringAfter stirring at 0° C. for 3 hr
3. customthe reaction mixture was quenched with water
4. extractionextracted with diethyl ether
5. dry with materialThe organic layer was dried over Na2SO4
6. concentrationconcentrated

ORD record

ord-1352dc5b9aa148388e942fce61f6bb9f

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08710245B2