Sodium Carbonate → HCID 67257891, compound

Participants

Reaction Steps

To a solution of 2-(5-ethylthiophen-2-yl)ethanol (1 g, 6.4 mmol, 1.1 eq) and aminoacetaldehyde dimethylacetal (612 mg, 5.83 mmol, 1 eq) was added CF3SO3H (2.7 g, 17.5 mmol, 3 eq) dropwise at 0° C. After stirring at room temperature overnight, the reaction mixture was diluted with water, adjusted pH to ˜8 with Na2CO3, and extracted with EtOAc. The organic layer was dried over Na2SO4, and concentrated. The crude product was purified by column chromatography.

Provenance & Evidence