HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(5-bromothiophen-2-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Thiopheneethanol | HCID 79400 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(5-bromothiophen-2-yl)ethanol | HCID 20750617 | — |
Reaction Steps
To a solution of 2-(thiophen-2-yl)ethanol (3 g, 23.4 mmol, 1 eq) and HOAc (5 mL) in CHCl3 was added NBS in portions at room temperature. After stirring at room temperature overnight, the reaction mixture was poured into water and extracted with CHCl3 twice. The combined organic layer was dried over Na2SO4, concentrated and purified by column chromatography to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710245B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a6676666007c4a4cb36296d636198a6c |
| Source note | uspto-grants-2014_04 |