Water → HCID 86682373, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(6,7-dihydro-4H-thieno[3,2-c]pyran-4-yl)-cyclopropanamine (1 g, 5.1 mmol) and Et3N (0.8 g, 7.5 mmol) in dry DCM (20 mL) at 0° C. was added ethyl chloroformate (0.8 g, 7.5 mmol) dropwise. After stirring at 0° C. for 4 h, water (20 mL) was added to quench the reaction. The mixture was extracted with DCM (3×50 mL) and the organic extract was dried over anhydrous Na2SO4. After filtration and concentration, the crude product was purified by column chromatography to give the title compound (1.1 g, 83%).

Provenance & Evidence