HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Thiophenecarboxaldehyde → 3-Thiophen-3-yl-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Thiophen-3-yl-acrylic acid ethyl ester | HCID 66914753 | 83.6% |
Reaction Steps
To a solution of thiophene-3-carbaldehyde (10 g, 89.3 mmol) in THF (500 mL) at 0° C. was added ethyl (triphenylphosphoranylidene)acetate (35 g, 100.5 mmol) in portions. After stirring overnight, the reaction mixture was concentrated and purified by column chromatography to give the title compound (13.6 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710245B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-4a99e82d39a8437bb5058c770520a595 |
| Source note | uspto-grants-2014_04 |