6-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazine → 6-(o-Fluorophenyl)-1,2,4-triazolo[4,3-b]-1,2,4-triazine

HRID 237105Notes

Reaction equation

HRID 237105 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[N:12][C:11]([NH:14][NH2:15])=[N:10][CH:9]=1.[CH:16]([O-])([O-])OCC>CCCCCC>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[N:10][C:11]2[N:12]([CH:16]=[N:15][N:14]=2)[N:13]=1

Participants

4

Reactant 2

HCID 125812906-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazineHCID 53630039Ethylorthoformate

Product 1

HCID 125813006-(o-Fluorophenyl)-1,2,4-triazolo[4,3-b]-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture of 3.8 g. of 6-(o-fluorophenyl)-3-hydrazino-1,2,4-triazine and 40 ml. of ethyl orthoformate is refluxed for 4 hours, cooled and poured into hexane. The solid is separated and washed with ethanol, giving the desired product as a yellow solid, m.p. 193°-196° C.

Workup

  1. additionA mixture of 3.8 g
  2. temperaturecooled
  3. customThe solid is separated
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-0e76f4a92a684ad887098231ead3d9b3
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Reaction notes

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