2,5-Dimethylthiophene → HCID 14452582, compound

Participants

Reaction Steps

To a solution of AlCl3 (29.5 g, 221 mmol) in CH2Cl2 (150 mL) was added 2,5-dimethyl thiophene (6.2 g, 55 mmol) followed by ethyl 2-chloro-2-oxoacetate (15.1 g, 110 mmol). The resulting mixture was stirred at room temperature for 12 h at which time the reaction mixture was filtered, diluted carefully with H2O and extracted with EtOAc. Removal of volatiles afforded mostly pure crude material, which was used in the next step without further purification.

Provenance & Evidence